152
scientific articles published from 2018 to 2024
2.467
SIGAPS points accumulated from 2018 to 2024
53%
of articles were published in international A- or B-ranked journals
4
randomized trials in progress
7
clinical trials with industrial partners in progress
593
patients included between 2018 and 2024
Clinical research
on endometriosis
The Institut Franco Européen Multidisciplinaire d'Endométriose (IFEM Endo) is developing an intense clinical research activity, which is internationally recognized.
The research activity follows different orientations:
analysis
patient data
Our center has its own "IFEM Endo" cohort, which has been collecting data from all patients since 2021. More than 9,500 patients participate in this registry, which helps to improve knowledge and the care pathway.
To improve our patients' knowledge and care pathways, IFEM Endo took part in the CIRENDO cohort (Cohorte Inter-Régionale Nord-Ouest des patientes opérées d'une Endométriose), which Prof. Horace Roman set up at Rouen University Hospital in June 2009, with the support of Rouen University Hospital (cohort promoter) and the G4 group (Lille, Rouen, Amiens and Caen University Hospital). This cohort enjoys wide international recognition, thanks to the large number of patients (over 3,500) followed over the long term. This cohort has enabled the publication of numerous clinical studies focusing on the surgical management of various forms of endometriosis, mainly of the digestive tract and ovaries. NCT02294825.
Today, our center benefits from its own "IFEM Endo" cohort, in which data are collected on all patients having a 1st appointment with our surgeons (unless they object). Since 2021, more than 9,500 patients have been enrolled in this registry, hosted by the NO ENDO platform, which enables long-term follow-up of our endometriosis patients. Numerous scientific articles have been published thanks to this cohort.
tests
clinics
Our doctors are committed to offering their patients the latest therapeutic and technological innovations through participation in clinical trials. Our aim is to constantly improve the quality of patient care.
The clinical trials we develop and/or participate in aim to :
- Improved diagnosis to overcome the medical wandering suffered by endometriosis patients
- Improving care pathways (drug treatment, surgical techniques, complementary therapies, etc.)
- Improving patients' quality of life.
List of clinical trials for which inclusions are open in our center and for which we are sponsor or investigating center:
- AdomiARM (interest in the salivary signature of endometriosis in the care of adolescents, promoted by ZIWIG)
- ENDOBEST (Impact of Ziwig Endotest® on the decision and management of patients with disabling chronic pelvic pain strongly suggestive of endometriosis and presenting with a negative or uncertain baseline imaging workup, promoted by ZIWIG)
- ENDO Inter (Evaluation of the impact of interference on Endotest Diagnostics), promoted by ZIWIG)
- GYNRNA (Evaluation of salivary RNA in patients undergoing surgery for gynecological pathology, promoted by ZIWIG)
- EFFORT (bi-centric study, with the University of Aarhus, Denmark) , Impact of Operation on Fertility for Women With Severe Endometriosis (EFFORT), NCT04610710
- ENDOFERT (Impact of complete surgery for colorectal infiltrating endometriosis on fertility, sponsored by Lille University Hospital) , NCT02948972
- ENDO RAS TRIAL (Contribution of robotics in complex surgery: Hysterectomy for adenomyosis and deep pelvic endometriosis. Randomized multicenter study, sponsored by GCS RAMSAY Santé)
- LYVENDO (Evaluation of the efficacy of an innovative Lyv Endo digital therapy medical device for the management of patients suffering from endometriosis, promoted by French start-up Lyv Healthcare.
List of trials in which we have participated and whose sponsors are various establishments or companies located in France or abroad:
- MESURE (MEdical versus SUrgical management of Rectal Endometriosis, national PHRC obtained by Pr Roman in 2013, whose promoter is the Rouen University Hospital), NCT01973816
- EndoHOME: Effect of Endocare home treatment on pain in women with chronic pelvi-perineal pain related to endometriosis.
- ENDO HIFU R2: Double-blind evaluation of the efficacy of high-intensity focused ultrasound treatment on symptoms in patients treated for rectal endometriosis compared with a sham intervention.
- LUCINE SINGLECARE : pain management in endometriosis using a virtual audiovisual method.
- ENDOSEARCH: the first non-invasive diagnostic test for endometriosis.
- EDAP TMS, ENDO HIFU R1: evaluation of high-intensity focused ultrasound (HIFU) treatment of rectal endometriosis.
- Morfologia degli eventi molecolari della Deeply Infiltrative Endometriosis, with Prof Andrea Modesti (Rome, Italy) and Prof Ilaria Tresoldi (Aarhus, Denmark) N° R S 217 19
- ENDOmiARN Saliva Test Study: Multicenter validation of the salivary miRNA signature in endometriosis
participate
to a research protocol
At the end of the consultation, your surgeon may suggest that you take part in a research protocol.
After explaining the purpose of the research, how it will be carried out, the benefits, the risks and your rights, you will be given an information sheet to read. You will then be given time to reflect on your decision. Whether or not you agree to take part, your decision will in no way affect the quality of future care. If you agree to take part, and after asking all your questions, your agreement will be obtained orally or in writing by signing a consent form. Your participation will be recorded in your medical file. You will then meet the clinical research team, who will guide you, ensure that the protocol runs smoothly and coordinate your care. They will inform you of your next follow-up appointments, check on test deadlines, study safety and regulations, liaise with your various specialists, and collect medical data useful for the research.Your rights
You can stop participating in a research protocol or the re-use of your data for research at any time, without justification, and without jeopardizing the quality of your care.Scientific articles
endometriosis
*The assessment of the scientific value of a publication is based on the SIGAPS system (Système d'Interrogation, de Gestion et d'Analyse des Publications Scientifiques), which was initiated at the CHRU de Lille in 2002 and aims to list and analyze scientific publications for establishments with medical research activities. The SIGAPS score is calculated according to journal category (rank A=8 points, B=6 points, C=4 points, D=3 points, E=2 points, NC=1 point) and the researcher's position among the authors, with the following coefficients: Author position 1=4 points, 2=3 points, 3=2 points, Intermediate=1 points, Second-to-last=3 points, Last=4 points. For example, an article with rank A as first author therefore has a score of 8×4, or 32 points. A journal's rank is established on the basis of the annual world ranking of scientific journals, by specialty (in our case, gynecology-obstetrics-fertility): the top 10% of journals are classified in rank A, the next 15% in rank B, the next 25% in rank C, the next 25% in rank D and the last 25% in rank E.
Last updated on Sep 11, 2025 @ 17:29